Abstract—Recently, the development of the Computer Aided Diagnoses (CAD) systems has been rapidly remarked. As one of the CAD systems, temporal subtraction technique can emphasize the temporal changes of interested regions by subtracting a previous image from a current image. However, subtraction artifacts are still remained due to mis-registration, which caused by the variation of pose and inhalation differences when a patient accepts CT inspection at different times. Therefore, high accurate registration technique between a previous image and a current image is necessary. The purpose of this paper is to propose a non-rigid warping algorithm in local image matching based on the feature-driven Free Formed Deformation (FFD). The proposal was performed on thoracic MDCT images and the satisfactory results were obtained.

Index Terms—temporal subtraction technique, computer aided diagnosis, non-rigid image registration, free formed deformation

Cite: Yuriko Yoshino, Takumi Tokisa, Hyoungseop Kim, Takatoshi Aoki, and Shoji Kido, "A 3-D Non-Rigid Warping Method Based on Free Formed Deformation for Temporal Subtraction on Thoracic MDCT Images," Journal of Image and Graphics, Vol. 4, No. 2, pp. 105-109, December 2016. doi: 10.18178/joig.4.2.105-109